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KMID : 0948220170210010034
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Keimyung Journal of Nursing Science
2017 Volume.21 No. 1 p.34 ~ p.40
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The Factors affecting Cognitive Function in Patients with High-grade Brain Cancers during Cancer-related Therapy
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Kim Sang-Hee
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Abstract
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Purpose: The purpose of this study was to investigate cognitive decline and its affecting factors such as tumor-related indicators and with or without intravenous infusion of vitamin B12 in patients with high-grade brain cancers.
Methods: Data on 43 patients with high-grade brain cancers who were admitted to the hospital for concurrent chemoradiotherapy(CCRT) in 2014 and met the inclusion criteria of the study were retrospectively analyzed. For comparative analysis, we investigated the factors affecting patients’ cognitive function using Seoul Neuropsychological Screening Battery Dementia version, and tumor-related factors such as grade, size, location, extent of tumor removal, and intravenous infusion of Vitamin B12. All factors were compared at the time of 6 weeks after CCRT.
Results: Patients with cognitive decline were 15 and other patients without cognitive decline were 28 after CCRT. The factors affecting cognitive decline were tumor grade, size, location, extent of tumor removal, and intravenous infusion of Vitamin B12. and these factors showed significantly different between with and without cognitive decline groups.
Conclusion: Early evaluation for cognitive decline will be needed for patients with high-grade brain cancers for their managing. Furthermore intravenous infusion of vitamin B12 is considered as therapeutic intervention for managing cognitive decline in the patients.
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KEYWORD
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High-grade brain cancer, Cognitive function, Cancer-related therapy
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